The HUPO plasma samples show significant differences compared to reference plasma collected according to the BioVisioN sample protocols (detailed in ). In our study, different protocols for EDTA/citrate specimen collection were investigated. A major finding is the detection of platelet-derived peptides in HUPO specimens. We searched the Swiss-Prot (www.expasy.org) database using the sequence retrieval system (entry tissue = platelet). Out of 104 retrieved precursor proteins, we found 35 to be present in the HUPO database and some have been identified by several groups (Supplementary Tab. 1).
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