Analysis with Selditof Ms of time zero effects of protease inhibitors in plasma

We used SELDI-TOF analysis to compare twenty samples in two groups, distinguished only by the presence or absence of protease inhibitors (PIs) at the time of collection. A number of peptide and protein mass/charge (m/z) peaks show statistically significant differences between the two groups, with m/z *6803 as representative data shown in Fig. 4. The particular m/z peaks show consistently higher signals in the presence of protease inhibitors, while far lower signal is observed for the untreated plasma samples.

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