Inherited Peripheral Neuropathies

Reactive Microglia

The peripheral myelin protein-22 PMP22 is a very hydrophobic glycoprotein and is highly expressed in compact PNS myelin. It has been mapped to the previously defined Tr locus on mouse chromosome 11. Comparison of marker genes on mouse chromosome 11 and human chromosome 17 revealed that PMP22 was also a candidate gene for the most common form of autosomal-dominant demyelinating hereditary peripheral neuropathy in humans, Charcot-Marie-Tooth disease type 1A CMT1A . Indeed, the entire PMP22 gene...