Airway Resistance And The Distribution Of Ventilation

Ventilatory air flow occurs down pressure gradients. Upon inspiration, the respiratory muscles generate subatmospheric Ppl, which are transmitted to the alveoli. Air flows into the lungs down a pressure gradient from the atmosphere to the alveoli. During expiration, the respiratory muscles compress the intra-pleural space, creating positive pressure in the alveoli that force air out to the atmosphere. Airway resistance is the primary determinant of the pressure gradient necessary to produce a given flow rate.

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