Aldosterone Regulates Ion Transport In Cnt And Principal Cells

The processes of Na+ reabsorption and K+ secretion in the connecting tubule and collecting duct are regulated by the mineralocorticoid hormone aldosterone. Aldosterone is produced by the adrenal cortex in the zona glomerulosa (see Chapter 40, the section on ''Physiology of the Mineralocorticoids''). It increases Na+ reabsorption and K+ secretion by the CNT and principal cells, and H+ secretion by the intercalated cells in the distal nephron. Aldosterone, like most steroids, is lipophilic and easily permeates cell membranes.

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