Vkb

Eject ACh 10 msec

FIGURE 10 Comparison of the EPP (A) and the response to iontophoretic application of ACh (B).

Eject ACh 10 msec

FIGURE 10 Comparison of the EPP (A) and the response to iontophoretic application of ACh (B).

from the motor end plate because there are no receptors for ACh at these more distant sites. The receptors for ACh are located at the neuromuscular junction. One additional insight has been obtained from the ionto-phoretic application of ACh. As indicated above, curare blocks the EPP. The action of curare could be at two basic sites, however. Curare could be acting to reduce the release of chemical transmitter from the presynaptic terminal, or, alternatively, it could have a postsynaptic effect. When ACh is artificially applied, the possibility of presynaptic changes is eliminated. Therefore, the reduction of the iontophoretic potential with curare is due to a postsynaptic action. As a result of these and other studies it is now known that curare is a competitive inhibitor of ACh. Curare binds with the same receptor site on the postjunctional membrane as does ACh. Although it binds with the receptors, it does not produce the resultant permeability changes.

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