Clinical Note

Most lung disease is patchy in nature, and leads to considerable differences in ventilation (Va) and perfusion (Q), and Va/Q heterogeneity. This increases the alveolar-arterial Po2 and, consequently, it can be difficult to distinguish between diffusion limitations and Va/Q heterogeneity.

Unfortunately, it is not possible to routinely measure Va/Q heterogeneity for diagnostic purposes, although rapid progress is being made in lung imaging techniques. However, sophisticated experimental techniques have been applied in special clinical studies and these

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