Contents

Contributors xiii

Preface xv

PART I: GENERAL PHYSIOLOGY

1. The Internal Environment 3

Stanley G. Schultz

2. Control of Cell Function 11

H. Maurice Goodman

3. Membrane Transport 37

Stanley G. Schultz

4. Resting Potentials and Action Potentials in Excitable Cells 71

John H. Byrne

5. Propagation of the Action Potential 89

John H. Byrne

6. Neuromuscular and Synaptic Transmission 97

John H. Byrne

7. Striated Muscle 123

Norman W. Weisbrodt

8. Smooth Muscle 137

Norman W. Weisbrodt

9. Autonomic Nervous System 145

Norman W. Weisbrodt

PART II: CARDIOVASCULAR PHYSIOLOGY 10 Hemodynamics 157

James M. Downey

11. Electrical Activity of the Heart 175

James M. Downey

12. The Electrocardiogram 187

James M. Downey

13. The Mechanical Activity of the Heart 201

James M. Downey

14. Regulation of Venous Return and Cardiac Output 215

James M. Downey

15. Regulation of Arterial Pressure 225

D. Neil Granger

16. Capillary Exchange 235

D. Neil Granger

17. Regulation of Regional Blood Flow 245

D. Neil Granger

PART III: RESPIRATORY PHYSIOLOGY

18. Structure and Function of the Respiratory System 259

Frank L. Powell, Jr.

19. Mechanics of Breathing 277

Frank L. Powell, Jr.

20. Oxygen and Carbon Dioxide Transport in the Blood 289

Frank L. Powell, Jr.

21. Pulmonary Gas Exchange 299

Frank L. Powell, Jr.

22. Control of Breathing 315

Frank L. Powell, Jr.

PART IV: RENAL PHYSIOLOGY

23. Functional Anatomy of the Kidney and Micturition 333

James A. Schafer

24. Renal Blood Flow and Glomerular Filtration 343

James A. Schafer

25. Mass Balance in Body Homeostasis and Renal Function 361

James A. Schafer

26. Reabsorption and Secretion in the Proximal Tubule 371

James A. Schafer

27. Reabsorption and Secretion in the Loop of

Henle, Distal Tubule, and Collecting Duct 391

James A. Schafer

28. Regulation of Body Fluid Osmolality 405

James A. Schafer

29. Regulation of Sodium Balance and Extracellular Fluid Volume 423

James A. Schafer

30. Renal Regulation of Potassium, Calcium, and Magnesium 437

James A. Schafer

31. The Role of the Kidney in Acid-Base Balance 447

James A. Schafer

PART V: GASTROINTESTINAL PHYSIOLOGY

32. Regulation 465

Leonard R. Johnson

33. Motility 479

Leonard R. Johnson

34. Secretion 497

Leonard R. Johnson

35. Digestion and Absorption 529

Leonard R. Johnson

36. Intestinal Electrolyte and Water Transport 547

Stanley G. Schultz

PART VI: ENDOCRINE PHYSIOLOGY

37. Introduction to Endocrine Physiology 559

H. Maurice Goodman

38. Pituitary Gland 573

H. Maurice Goodman

39. Thyroid Gland 587

H. Maurice Goodman

40. Adrenal Glands 607

H. Maurice Goodman

41. The Pancreatic Islets 637

H. Maurice Goodman

42. Hormonal Regulation of Fuel Metabolism 659

H. Maurice Goodman

43. Hormonal Regulation of Calcium Metabolism 679

H. Maurice Goodman

44. Hormonal Growth Control 701

H. Maurice Goodman

45. Hormonal Control of Reproduction in the Male 719

H. Maurice Goodman

46. Hormonal Control of Reproduction in the

Female: The Menstrual Cycle 737

H. Maurice Goodman

47. Hormonal Control of Reproduction in the

Female: Pregnancy and Lactation 757

H. Maurice Goodman

PART VII: CENTRAL NERVOUS SYSTEM PHYSIOLOGY

48. Organization of the Nervous System 779

Dianna A. Johnson

49. Sensory Receptors of the Somatosensory System 789

Dianna A. Johnson

50. Central Projections of the General Somatosensory

System 797

Dianna A. Johnson

51. The Visual System 807

Dianna A. Johnson

52. The Vestibular System 831

Dianna A. Johnson

53. The Auditory System 839

Dianna A. Johnson

54. The Chemical Senses: Smell and Taste 849

Dianna A. Johnson

55. Lower Motor Neurons of the Spinal Cord and Brain Stem 861

Dianna A. Johnson

56. Sensory and Motor Pathways Controlling Lower

Motor Neurons of the Spinal Cord 867

Dianna A. Johnson

57. The Motor Cortex 877

Dianna A. Johnson

58. The Basal Ganglia 881

Dianna A. Johnson

59. The Cerebellum 889

Dianna A. Johnson

60. Neuronal Control of Mood, Emotion, and

State of Awareness 897

Dianna A. Johnson

61. Learning and Memory 905

John H. Byrne

PART VIII: INTEGRATIVE PHYSIOLOGY

62. Body Temperature Regulation 921

James A. Schafer

63. Exercise 933

Frank L. Powell, Jr.

64. Heart Failure and Circulatory Shock 941

James M. Downey

65. Diabetic Ketoacidosis 949

Stanley G. Schultz

66. Maternal Adaptations in Pregnancy 953

H. Maurice Goodman

Index 967

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