FIGURE 16 Cellular events in the regulation of prolactin secretion. Steps in basal synthesis and secretion are indicated by the pale blue arrows. Effects of dopamine are shown by the dark blue arrows. Effects of estradiol are shown in black. Dashed lines indicate inhibition. Gia and Py are the subunits of the heterotrimeric inhibitory G protein. AC, adenylate cyclase; cAMP, cyclic adenosine monophosphate; PKA, protein kinase A; E2, estradiol; ER, estrogen receptor; PRL, prolactin. Not shown: TRH increases prolactin secretion through activation of its heptihelical receptor, which is coupled through Gaq to phospholipase Cp and causes release of inositol trisphosphate, diacylglyceride, and increased intracellular calcium.

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