Maurice Goodman

Specialization of Cellular Function 12 Regulation of Gene Expression 12 Protein Degradation 17 Regulation of Protein Function 17 Coordination of Cellular Activity with Changing Demands of the Internal and External Environment 18 Physiological Signals 19 Responses of Target Cells 20 Characteristics of Receptors 20 Signal Transduction Through Receptors That Reside in the Plasma Membrane 21

The G-Protein-Coupled Receptor

Superfamily 21 Cyclic GMP 27 Receptor Channels 28

Receptors That Signal Through Tyrosine Kinase 28 Intracellular Receptors 31 Integration of Simultaneous Signals 32 Biosynthesis, Storage, and Secretion of Chemical Signals 33 Secretory Granules and Vesicles 33 Exocytosis 34

Clearance of Chemical Messages 35

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