Prc

pregnenolone

pregnenolone

FIGURE 20 Consequences of a partial block of cortisol production by defects in either 11- or 21-hydroxylase. Pregnenolone is diverted to androgens, which exert no feedback activity on ACTH secretion. The thickness of the arrows connotes relative amounts. The broken arrows indicate impairment in the inhibitory limb of the feedback system. Administration of glucocorticoids shuts down androgen production by inhibiting ACTH secretion.

^ cortisol androgens

FIGURE 20 Consequences of a partial block of cortisol production by defects in either 11- or 21-hydroxylase. Pregnenolone is diverted to androgens, which exert no feedback activity on ACTH secretion. The thickness of the arrows connotes relative amounts. The broken arrows indicate impairment in the inhibitory limb of the feedback system. Administration of glucocorticoids shuts down androgen production by inhibiting ACTH secretion.

Adrenal Medulla

Adrenal Medulla tyrosine tyrosine dihydroxyphenylalanine (DOPA)

dihydroxyphenylalanine (DOPA)

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