0 0.4 0.8 1.2 1.6 2.0 2.4 2.8 Amplitude of End-plate Potentials (mV)
FIGURE 17 Quantal nature of transmitter release. (A) In a low-Ca2+ solution, the motor axon is repeatedly stimulated, and the amplitude of the EPP is monitored. In such a solution, the amplitude of the EPP is small and variable. Asterisks indicate spontaneous MEPPs. (Modified from Liley AW. J Physiol 1956; 133:571-587.) (B) A histogram showing the number of times EPPs of various amplitudes are recorded in the low-Ca2+ solution. There are many EPPs that have an amplitude identical to the amplitude of the MEPP (0.4 mV). Other peaks are multiples of the first. (Modified from Boyd IA, Martin AR. J Physiol 1956; 132:74-91.)
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