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Sodium Concentration (mM)

FIGURE 7 Plot of the peak amplitude of the action potential vs. the extracellular concentration of Na+. The solid line is a prediction of the Nernst equation with an estimated intracellular Na+ concentration for this cell of 17 mmol/L. (Modified from Nastuk WL, Hodgkin AL. J Cell Comp Physiol 1950; 35:39.)

during the peak of the action potential the membrane suddenly switches from a high permeability to K+ to a high permeability to Na+

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