20 day

FIGURE 9 Effects of continuous administration of aldosterone to a normal man. Aldosterone (3-6 mg/day) increased potassium excretion and sodium retention, represented here as a decrease in urinary sodium. The increased retention of sodium, which continued for 2 weeks, caused fluid retention and hence an increase in body weight. The subject ''escaped'' from the sodium-retaining effects but continued to excrete increased amounts of potassium for as long as aldosterone was given. (From August JT, Nelson DH, Thorn GW. Response of normal subjects to large amounts of aldosterone. J Clin Invest 1958;37:1549-1559.)

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