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Cardiovascular and Tissue Oxygen Transport reaction between CO and hemoglobin is decreased by hemoglobin oxygenation, and Dlco has a chemical reaction rate component (0 Vc) similar to Dlo2. In lung disease, Dlco may be affected by other factors such as unequal distributions of alveolar volume, pulmonary blood flow, and diffusing properties. Such factors explain why morphometric estimates of diffusing capacity, based on anatomic measurements of the blood-gas barrier surface area, thickness, etc., are about twice as large as functional measurements of diffusing capacity. Because other factors can affect Dlco measurement, it is sometimes referred to as a transfer factor instead of the diffusing capacity.

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