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FIGURE 18 Effects of cortisone on growth in hypophysectomized rats given growth hormone replacement. The growth-promoting response to GH, measured as a change in either body weight or length, decreased progressively as the dose of cortisone was increased from 0.1 to 1.0 mg per day. The decrease in body weight seen when 1.0 mg per day of cortisone was given probably resulted from net breakdown of muscle mass (see Chapter 40). (From Soyka LF, Crawford JD, J Clin Endocrinol Metab 1965; 25:469-475. With permission.)

but we do not know if this is a cause or an effect of the decreased action of GH.

Suggested Readings

Baumann G. Growth hormone heterogeneity: genes, isohormones, variants and binding proteins. Endocrine Rev 1991; 12:424-449.

Clemmons DR. Use of mutagenesis to probe IGF-binding protein structure/function relationships. Endocrine Rev 2001; 22:800-817.

Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocrine Rev 1998; 19:717-797.

Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocrine Rev 1995; 16:3-34. LeRoith DE, Bondy C, Yakar S, Liu JL, Butler A. The somatomedin hypothesis: 2001. Endocrine Rev 2001; 22:53-74. Ohlsson C, Bengtsson B-A, Isaksson OGP, Andreassen TT, Slootweg

MC. Growth hormone and bone. Endocrine Rev 1998; 19:55-79 Rosenfeld RG, Rosenbloom AL, Guevara-Aguirre J. Growth hormone (GH) insensitivity due to primary GH receptor deficiency. Endocrine Rev 1994; 15:369-390. Smit L, Meyer DJ, Argetsinger LS, Schwartz J, Carter S.-C. Molecular events in growth hormone-receptor interaction and signaling. In: Kostyo JL, Ed., Handbook of physiology, Section 7: The endocrine system, Vol. V: Hormonal control of growth, New York: Oxford University Press, 1999, pp. 445-480.

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