Iv

3 Voltage-sensing Region

FIGURE 14 Model of the principle structural and functional unit of the voltage-gated Na+ channel.

move into the channel pore and cause its blockade. Finally, the Na+ channel can be regulated by protein phosphorylation. Specifically, the region that links domains I and II contains phosphorylation sites for cyclic adenosine monophosphate (cAMP)-dependent protein kinase, whereas the region that links domains III and IV contains a phosphorylation site for protein kinase C.

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