John H Byrne

Types of Synaptic Transmission 98 Synaptic Transmission at the Neuromuscular

Junction 98 End-Plate Potential 99 Propagation of the End-Plate Potential 101 Acetylcholine Hypothesis for Synaptic Transmission at the Neuromuscular Junction 101 Role of Acetylcholinesterase 103 Iontophoresis of Acetylcholine 103 Ionic Mechanisms Underlying the End-Plate Potential 104 Structure of the Ligand-Gated Acetylcholine Receptor 105

Presynaptic Events Underlying the Release of Neurotransmitter 106 Voltage-Dependent Release of Neurotransmitter 106 Role of Ca2+ in Transmitter Release 106

Quantal Nature of Acetylcholine Release 108 Summary of the Sequence of Events Underlying Synaptic Transmission at the Skeletal Neuromuscular Junction 110 Synaptic Transmission in the Central Nervous System 112

Mechanisms for Excitation, Inhibition, and Integration of Synaptic Potentials 113

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