Extracellular Recording of the Nerve Action
Potential 72 Intracellular Recording of the
Resting Potential 72 Intracellular Recording of the Nerve Action
Potential 73 Ionic Mechanisms of the Resting Potential 74 Bernstein's Hypothesis for the
Resting Potential 75 Testing Bernstein's Hypothesis 75 Goldman-Hodgkin-Katz Equation 76 The Sodium Hypothesis for the Nerve Action
Potential 76 Applying the Goldman-Hodgkin-Katz Equation to the Action Potential 78 The Concept of Voltage-Dependent Na+ Permeability 78
Testing the Concept of Voltage-Dependent Na+
Permeability: The Voltage-Clamp Technique 79 Molecular Basis for the Regulation of Na+
Permeability 80 Structure of the Voltage-Gated Na+ Channel 80 Na+ Inactivation 82
Role of Voltage-Dependent K+ Conductance in
Repolarization of the Action Potential 83 Specificity of Ion Channels Underlying the Action
Potential 85 Do Changes in Na+ and K+ Concentrations Occur
During Action Potentials? 85 Threshold, Accommodation, and Absolute and Relative Refractory Periods 86 Threshold 86
Absolute and Relative Refractory Periods 86 Accommodation 87
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