John H Byrne

Extracellular Recording of the Nerve Action

Potential 72 Intracellular Recording of the

Resting Potential 72 Intracellular Recording of the Nerve Action

Potential 73 Ionic Mechanisms of the Resting Potential 74 Bernstein's Hypothesis for the

Resting Potential 75 Testing Bernstein's Hypothesis 75 Goldman-Hodgkin-Katz Equation 76 The Sodium Hypothesis for the Nerve Action

Potential 76 Applying the Goldman-Hodgkin-Katz Equation to the Action Potential 78 The Concept of Voltage-Dependent Na+ Permeability 78

Testing the Concept of Voltage-Dependent Na+

Permeability: The Voltage-Clamp Technique 79 Molecular Basis for the Regulation of Na+

Permeability 80 Structure of the Voltage-Gated Na+ Channel 80 Na+ Inactivation 82

Role of Voltage-Dependent K+ Conductance in

Repolarization of the Action Potential 83 Specificity of Ion Channels Underlying the Action

Potential 85 Do Changes in Na+ and K+ Concentrations Occur

During Action Potentials? 85 Threshold, Accommodation, and Absolute and Relative Refractory Periods 86 Threshold 86

Absolute and Relative Refractory Periods 86 Accommodation 87

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