20 sec cAMP-dependent protein kinase, protein kinase A (PKA), which phosphorylates a channel protein or protein associated with the channel. A conformational change in the channel is produced which then leads to a change in ionic conductance. Thus, in contrast to a direct conformational change produced by the binding of a receptor to the receptor-channel complex, in this case a conformational change is produced by protein phosphorylation. Indeed, phosphorylation-dependent channel regulation is one of the general features of slow PSPs.
Another interesting feature of slow synaptic responses is that they are sometimes associated with decreases rather than increases in membrane conductances. For example, the particular channel illustrated in Fig. 25 is selectively permeable to K+ and is normally open. As a result of the activation of the second messenger, the channel closes and becomes less
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