Key Points continued

to the accumulation of mucous-like extracellular proteins leading to myxedema.

• Mechanism of thyroid hormone action: Thyroid hormone receptors are transcription factors that are bound to response elements of a variety of genes whether or not T3 is present, and they may act as transcription repressors in the absence of the hormone.

• Secretion of T3 and T4 is stimulated by TSH, which is released from the pituitary in response to thyrotropin-releasing hormone (TRH) secreted by the hypothalamus.

• T3 and T4 inhibit secretion of TSH in a typical negative arrangement. T3 and T4 decrease the sensitivity of pituitary thyrotropes to TRH by down-regulating TRH receptors.

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