Key Points continued

• The adolescent growth spurt that follows puberty results from increased secretion of gonadal hormones and in males depends upon extragonadal conversion of androgens to estrogens.

• The pubertal growth spurt results from increased amplitude of GH secretory pulses induced by gonadal steroid hormones.

• Estrogens hasten epiphyseal closure and therefore limit growth.

• Androgens directly stimulate growth of soft tissue (e.g., muscle).

• Normal growth and good health require optimal amounts of glucocorticoids but at high concentrations antagonize the growth promoting actions of GH.

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