Receptors That Signal Through Tyrosine Kinase

A large group of agents, including hormones, cyto-kines, and growth factors, stimulate their target cells by exciting receptors that signal through activated tyrosine kinases (Table 3). The intracellular portions of the receptor tyrosine kinases have intrinsic tyrosine kinase activity. The tyrosine-kinase-associated receptors have no intrinsic tyrosine kinase activity, but the intracellular domain contains a sequence of amino acids that interacts with cytosolic tyrosine kinase molecules of the Janus kinase (JAK) family (Fig. 17). Although these receptors belong to several different structural families,

2. Control of Cell Function

TABLE 3 Some Examples of Tyrosine-Kinase-Dependent Receptors
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