Regulation Of Hormone Secretion

For hormones to function as carriers of critical information, their secretion must be turned on and off at precisely the right times. The organism must have some way of knowing when there is a need for a hormone to be secreted and when that need has passed. The necessary components of endocrine regulatory systems include the following:

1. Detector of an actual or threatened homeostatic imbalance.

2. Coupling mechanism to activate the secretory apparatus.

3. Secretory apparatus.

4. Hormone.

5. End organ capable of responding to the hormone.

6. Detector to recognize that the hormonal effect has occurred, and that the hormonal signal can now be shut off, usually the same as component 1.

7. Mechanism for removing the hormone from target cells and blood.

8. Synthetic apparatus to replenish hormone in the secretory cell.

As we discuss hormonal control, it is important to identify and understand the components of the regulation of each hormonal secretion because (1) derangements in any of the components are the bases of endocrine disease and (2) manipulation of any component provides an opportunity for therapeutic intervention.

Negative Feedback

Secretion of most hormones is regulated by negative feedback. Negative feedback means that some

(A) Capture Antibodies

ReporierAntibody

ReporierAntibody

(B) Hormone

FIGURE 4 Sandwich-type assay. (A) The first (capture) antibody linked to a solid support such as an agarose bead. (B) The hormone to be measured. (C) The second (reporter) antibody linked to an enzyme, which upon reacting with a test substrate gives a colored product. In this model, the amount of reporter antibody captured is directly proportional to the amount of hormone in the sample being tested.

(B) Hormone

FIGURE 4 Sandwich-type assay. (A) The first (capture) antibody linked to a solid support such as an agarose bead. (B) The hormone to be measured. (C) The second (reporter) antibody linked to an enzyme, which upon reacting with a test substrate gives a colored product. In this model, the amount of reporter antibody captured is directly proportional to the amount of hormone in the sample being tested.

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Get Rid of Gallstones Naturally

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