Total Body Water

The volume of TBW can be determined using a substance that can rapidly permeate cell membranes and distribute itself uniformly throughout the ECF and ICF compartments. One commonly used substance for this purpose is antipyrine, which is highly lipid soluble and inert. Other substances that can be used for this purpose are isotopic forms of water such as deuterated water or tritiated water. As illustrated in Fig. 5C, this measurement is complicated because these substances are lost from the body via every route open for the loss

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