The cellular and functional aspects of WAT and BAT ontogeny have been studied, including examination of expression of the WAT marker gene (leptin), the BAT marker gene (UCP-1), and a number of other genes associated with WAT and BAT development. The ontogeny and regulation of adipose tissue leptin gene expression have been examined.[8,9] Additional studies are necessary to determine the ontogeny of the response of leptin expression to fasting and other modulators as influenced by depot and species.

Furthermore, there is little to no information on the ontogeny of adipocyte expression of other regulatory factors expressed and secreted by rodent and human adipocytes.

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