Compelling evidence emerged two decades ago that the ovary produces nonsteroidal compounds inhibins that are involved in regulating FSH secretion. Inhibins provide the chemical signal indicating the number of growing follicles in the ovary to the pituitary gland to reduce the secretion of FSH to the level that maintains the species-specific number of ovulations. In the mare, where application of the conventional ET technique is impeded by the lack of a suitable superovulation treatment, active immunization has been shown to increase superovulation. Active immunization against inhibin, as well as against the androgen androstenedione, is used commercially to induce mild superovulation in sheep[8] and goats.[9]

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