Mathematical, computer-based models of metabolism relevant to the animal sciences extend from detailed models of energy input:output relationships established with intact animals, such as those developed by early workers in nutritional energetics in the late 1800s and used in current feeding systems to compute the nutrient requirements of animals, to the detailed models of enzyme kinetics pioneered by Garfinkel and his colleagues in the 1950s. Because of this range of applications, the authors of this presentation had considerable discretion in deciding the focus of this article. We elected to forgo discussion of models of enzymes, individual metabolic pathways, and whole-animal metabolism, except by way of background, and to focus on models of the metabolisms of individual tissues in ruminant animals.

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