Bone is a ''specialized form of connective tissue.'' The role of the skeleton is twofold: structural support and calcium homeostasis. In addition to bone, cartilage is an essential component in skeletal function. Cartilage serves as a precursor of endochondral bone formation and minimizes friction at bone joints. Bone is composed of an organic matrix of collagen and proteoglycans (osteoid) embedded with hydroxyapatite crystals containing calcium and phosphorus salts. The osteoid matrix is primarily type I collagen, whereas in cartilage tissue, the predominant component is type II collagen.

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