Inbred strains of animals have been a major mainstay of biological research for years. These animals have been bred by brother-sister mating for many generations until they are essentially all genetically identical within each sex. Experimental analysis is then simplified, because variations in response to experimental treatment due to variations in genetic background can be eliminated.
Clearly, generating homozygous inbred lines in larger animals with long generation times and small numbers of offspring is not readily achievable. By somatic cell nuclear transfer, we can produce larger numbers of genetically identical animals, which reduces variability in experiments. This consequently reduces the number of animals needed for an experiment.
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