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Rifampin inhibits RNA synthesis by binding to the p-subunit of RNA polymerase. As with fluoroquinolone resistance, mutations in the target enzyme are the most common mechanism of resistance.1-2-1

Metronidazole interferes with DNA replication and is particularly useful against anaerobic bacteria and protozoa. Resistance to metronidazole is via failure to activate the antibiotic and apparently involves the decreased production of flavadoxin, a protein that activates metro-nidazole.[4]

Oxazolidinones such as Zyvox inhibit protein synthesis by binding to the 50S ribosomal subunit. Resistance to oxazolidinones is mediated by mutations to the 23S ribosomal RNA.

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