Tetracycline and the derivatives oxytetracycline, doxycy-cline, and minocycline inhibit protein synthesis by binding to the 30S ribosomal subunit. Resistance to tetracyclines is mediated by one of two mechanisms. Both energy-dependent efflux pumps and protection of the ribosome by production of a protein that interacts with the ribosome and renders it unaffected by tetracycline are widely used by bacteria to confer resistance to these antibiotics.[2'6] There is also a rare resistance to tetracy-cline that is mediated by inactivation of the antibiotic. The significance of this mode of tetracycline resistance is not known.

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