Tissue Origin

Four cell types in bone (osteoblasts, osteocytes, bone lining cells, and osteoclasts) and three in cartilage (chondroblasts, chondrocytes, and chondroclasts) are responsible for the synthesis and maintenance of bone and cartilage matrix. The osteoclasts and chondroclasts are of hemopoietic stem cell origin, whereas the remaining cell types differentiate from mesenchymal stem cells experiencing different local environmental inputs (e.g., oxygen tension or extracellular hormonal signaling).

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