Antibiotics and Antiinfective Agents

■ Penicillins, cephalosporins, and erythromycin are safe in pregnancy.

■ Aminoglycosides (streptomycin)—risk of deafness

■ Trimethoprim use in T1 is associated with increased risk of birth defects.

■ Tetracyclines deposit in developing osseous sites and inhibit bone growth. They bind to developing enamel and discolor the teeth. Deciduous teeth are affected between 26 weeks' GA and infant age of 6 months.

■ Doxycycline has no teratogenic risk in T1.

■ Quinolones (Ciprofloxacin, Norfloxacin) have a high affinity for cartilage and bone tissue ^ may cause arthropathies in children.

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