■ Phenytoin decreases absorption of folate and decreases serum folate and causes craniofacial, limb, and mental defects.

■ Valproic acid and carbamazepine use is associated with a 1% risk of neural tube defects.

Heparin is the drug of choice in pregnant patients who require anticoagulation.

Low-molecular-weight heprain may be used in pregnancy.

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