Endometrial Cancer

GENERAL FACTS

An estrogen-dependant neoplasm that begins as proliferation of normal tissue: Over time, chronic proliferation becomes hyperplasia (abnormal tissue) and, eventually, neoplasia. Endometrial cancer is the most common gynecologic cancer. Most cases (> 75%) are diagnosed in postmenopausal women.

CLINICAL PRESENTATION

Abnormal bleeding is present in 90% of cases:

■ Bleeding in postmenopausal women (classic)

■ Meno/metrorrhagia (in premenopausal cases)

Pap smears are not diagnostic, but a finding of AGCUS (abnormal glandular cells of unknown significance) leads to further investigation.

Endometrial cancer is the most common gynecologic cancer.

DIFFERENTIAL DIAGNOSIS OF POSTMENOPAUSAL BLEEDING

Exogenous estrogens Atrophic endometritis/vaginitis Endometrial cancer Endometrial/cervical polyps

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