Luteal Phase Days 14 Through

The effect of LH on the follicle was to change its secretion from estradiol to progesterone. This happens before ovulation.

The corpus luteum survives only about 11 days in the absence of hCG, during which time it continues progesterone secretion.

Progesterone causes the endometrium to mature in preparation for possible implantation. It becomes highly vascularized with increased gland secretion.

Progesterone also causes inhibition of FSH and LH release.

If fertilization does not occur, the corpus luteum dies, progesterone levels fall, and the cycle begins again.

AMENORRHEA

Main event of menstruation: Absence of progesterone causes endometrial sloughing. Two main events in follicular phase:

■ FSH causes follicle maturation and estrogen secretion.

■ Estrogen causes endometrial proliferation.

Main event of ovulation: LH surge causes oocyte to be released.

Main events of luteal phase: Corpus luteum secretes progesterone, which causes:

■ Endometrial maturation

The corpus luteum would be maintained after fertilization by human chorionic gonadotropin (hCG) released by the embryo.

Primary amenorrhea: Absence of menses by age 16

Secondary amenorrhea: Absence of menses for > 6 months in a woman who previously had normal menses

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