Pathophysiology of Hypertension in Pregnancy

Normal

Arachadonic acid triggers two pathways:

Prostacycline: Decreases blood pressure via:

■ Decreased vasoconstriction

■ Increased uteroplacental blood flow Thromboxane: Increases blood pressure via:

■ Increased vasoconstriction

■ Decreased uteroplacental blood flow

The only cure for hypertension in pregnancy (except preexisting chronic HTN) is delivery.

Hypertension-related deaths in pregnancy account for 15% (second after pulmonary embolism) of maternal deaths.

In Pregnancy-Hypertensive States

The balance is thought to be tipped toward the thromboxane pathway.

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