Arachadonic acid triggers two pathways:
Prostacycline: Decreases blood pressure via:
■ Decreased vasoconstriction
■ Increased uteroplacental blood flow Thromboxane: Increases blood pressure via:
■ Increased vasoconstriction
■ Decreased uteroplacental blood flow
The only cure for hypertension in pregnancy (except preexisting chronic HTN) is delivery.
Hypertension-related deaths in pregnancy account for 15% (second after pulmonary embolism) of maternal deaths.
In Pregnancy-Hypertensive States
The balance is thought to be tipped toward the thromboxane pathway.
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