Treatment of Recurrent Cancer

■ Patients may only be treated for cure if disease is confined to pelvis.

■ Patients with central recurrence after radical hysterectomy are treated with radiation.

■ Patients previously treated with radiotherapy are only treated by radical pelvic surgery.

■ Chemotherapy:

■ Response rates higher with combination therapy

■ Most combinations include platinum.

■ Response rates = 50 to 70% for 4 to 6 months of life.

Women who took DES themselves during pregnancy have a 1.35% increased relative risk of breast cancer.

CLEAR CELL ADENOCARCINOMA OF CERVIX

Incidence in women exposed in utero to diethylstilbestrol (DES) = 1:1000

Who? Ages 16 to 27; median age = 19 years

Overall survival rate—80%

5-year survival rate for stage I disease—> 90%

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