As well as inflammation, there are abnormalities of both coagulation (clot formation) and fibrinolysis (break down of clot) as illustrated in Figure 7.2.

Increased coagulation driven by pro-inflammatory mediators, endothelial cell injury, tissue factor expression, and thrombin production

Figure 7.2 Abnormalities of coagulation and fibrinolysis

The many inflammatory mediators that are released promote coagulation. In addition, infectious agents can cause endothelial damage themselves, which also promotes coagulation. At each step in the cycle auto-amplification occurs, accelerating the coagulation abnormalities. Proinflammatory cytokines, such as interleukin 1A, interleukin 1B, and TNF, induce the expression of tissue factor (TF) on endothelial cells and monocytes initiating coagulation. TF is a key mediator between the immune system and coagulation and is the principle activator of coagulation causing large amounts of thrombin to be generated.

Was this article helpful?

0 0
How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment