Receptors are important to know about in order to understand how inotropes work. There are four main types of receptor in the circulation (Table 6.2).
All adrenoreceptors act via G proteins and cyclic AMP at the cellular level. Down-regulation of coronary pi adrenoreceptors occurs in patients who are on long-term p blockers or who have chronic cardiac failure because of prolonged excess endogenous catecholamine release. Down-regulation also occurs with prolonged exogenous catecholamine administration.
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