History of Diuretics

Diuretic Cartoons

Department of Medicine, Baylor College of Medicine, Houston, Texas 77030 Diuretics, as therapeutic agents that act on the kidney to increase salt and water excretion, have a relatively short history. On the other hand, the very reason for which diuretics were developed, i.e., mobilization of excess body fluids, has a long history which dates back to the beginnings of medicine. No history of diuretics would be complete without some consideration of this long prelude, which is particularly...

The Use of Diuretics in the Treatment of Ascites and Edema in Hepatic Cirrhosis

Salt Poor Albumin For Ascites

Seldin* Department oj Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246 and *University oj Texas Health Sciences Center, Dallas, Texas 75235 Cirrhosis of the liver is a major cause of salt and water retention. The tendency for accumulating fluid to localize in the peritoneal cavity is typical of cirrhosis and is far more pronounced than in congestive heart failure or the nephrotic syndrome. Although peripheral edema does occur with cirrhosis,...

Mechanism of Hypokalemia Induced Glucose Intolerance

The precise molecular mechanism of hypokalemia-induced glucose intolerance is not completely understood however, the bulk of clinical and experimental evidence indicates that glucose-mediated beta cell insulin release plays a major role. Studies in normal volunteers have shown that thiazide-induced potassium deficiency sufficient to produce sustained hypokalemia is associated with decreased glucose utilization and subnormal plasma insulin response to hyperglycemia of 125 mg dl (hyperglycemic...