Mechanism Of Action Of Amiloride Effect on Renal Calcium Transport

Amiloride inhibits sodium transport in the late distal tubules, likely connecting tubules, and other epithelial cells by blocking sodium channels [4]. Recently, it has been shown that amiloride inhibits sodium entry into the cells and hyper-polarizes the luminal and basolateral membranes. The latter effect, in turn, stimulates calcium influx into the cells and produces a sustained rise of intracellular calcium concentration. Calcium influx and rise of intracellular calcium concentration is inhibited with calcium channel blockers (dihydropyri-dine type).

Amiloride Effect Tubule

FIGURE 4. Sites and mechanisms of actions of diuretics on renal tubular calcium reabsorption. Symporters and antiporters are depicted as open circles. Channels are indicated by two lines interrupting a membrane. Shown are DCT diuretics (thiazides and indapamide), loop diuretics (furo-semide), Na channel blockers (amiloride).

Lumen Blood

Indapamide Mechanism Action

DCT Diuretics

Na Channel Blockers

Lumen Blood

DCT Diuretics

Lumen Blood

Na Channel Blockers

FIGURE 4. Sites and mechanisms of actions of diuretics on renal tubular calcium reabsorption. Symporters and antiporters are depicted as open circles. Channels are indicated by two lines interrupting a membrane. Shown are DCT diuretics (thiazides and indapamide), loop diuretics (furo-semide), Na channel blockers (amiloride).

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