Unlike standard diuretics, the agents described in this chapter do not block specific transporter proteins, but tend to alter the physiological control processes which govern salt and water excretion in the normal animal. The increased specificity of action of these agents may make them useful in certain defined circumstances, but in general these agents act as weaker diuretics and are not in large-scale clinical use. Each of these agents acts on distinct portions of the nephron, which is shown schematically in Fig. 1.

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