Atopic Eczema

A vast array of clinical entities
Actinic keratoses
Additional comment
Additional comments
Adjunctive therapy for tinea capitis in adults and children
Adverse effects - 2 3 4
Aetiology - 2 3
Aetiology and risk factors 4 5 6 7 8 9 10 11 12 13 14 15
Aetiology56
Aetiologyrisk factors - 2 3 4
Aims for primary prevention
Aims of treatment - 2
Aims of treatment and relevant outcomes - 2 3 4 5 6 7 8
Allopurinol
And if the treatment still does not work
Antiangiogenic agents
Antimalarials Benefits
Applying the evidence back to the patient
Asking a clear question
Asking an answerable question By
Azathioprine
Azelaic acid Efficacy
Back to the individual patient
Background - 2
Background Definition - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Being explicit and systematic
Benefits - 2
Benefits and harms 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43
Blood
Books J
Bowens disease - 2
Box 102 Examples of pharmacoepidemiological methods
Box 151 The quality of evidence rating system reported by Cox et al2
Box 171 In order to qualify as a case of atopic eczema the person must have the following6
Box 21 What evidencebased dermatology is not
Box 22 The five steps of practising evidencebased dermatology
Box 281 Quality of evidence scale employed by the British Association of Dermatology guidelines derived from the US Task Force on Preventative Care Guidelines3738
Box 331 The quality of evidence scale system employed by Cox and colleagues147
Box 411 Skin phototype
Box 81 The six steps of undertaking a systematic review
Box 93 Ways to enhance the impact of positive studies or reduce the impact of negative studies
Bridging the communication gap
Case scenario - 2
Cheating
Chemical peels
Childhood alopecia areata
Chronic plaque psoriasis
Ciclosporin - 2
Ciclosporin Benefits 3
Clinical implications
Clinical patterns
Clinical scenarios Scenario
Combination therapy
Combination TSEB regimens
Combined therapies Efficacy
Comment - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48
Comment on multifacet strategies to increase sunscreen use and sun protective behaviour
Comment on sunscreen use and melanoma risk 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71
Commentimplications for clinical practice - 2 3 4
Commentimplications for practice
Comments - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25
Communicating risks
Complications
Compression Benefits - 2
Concealing the sequence from recruiters
Conclusion
Conclusions - 2 3 4 5 6 7
Contacting the Cochrane Skin Group
Contents
Corticosteroids
Cost analysis
Costbenefit analysis
Costutility analysis
Cryosurgery Benefits
Cryotherapy - 2
Current recommendations
Dapsone
Data abstraction
Dde Murrell
Definition - 2 3
Definitions
Definitions of quality validity and bias
Dermatomyositis
Diagnosis - 2 3
Diagnostic tests - 2 3 4 5 6 7
Diagnostic tests79
Do the outcomes make sense to me
Does PASI mean anything to you
Does the treatment fit in with my patients values and beliefs
Drawbacks - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51
Editorial process
Education and information for selfcare
Effectiveness - 2 3 4 5 6 7 8 9 10 11
Efficacy - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106
Electrodesiccation and curettage
Epidemiological studies the most comprehensive source of data
Etoposide
Etretinateacitretinisotretinoin Efficacy
Evidencebased Dermatology
Evidencebased medicine where do we go from here
Evidencebased paralysis
Expert opinion
Extremely common disorders
Features
Finding the best evidence
Fluorouracil 5FU
For clinical practice healthcare providers
For research research agencies and researchers
Framework
Fumarates
General comments
Glycolic acid Efficacy
Gold
Haematological malignancies
Hand searching
Harms - 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Herbal treatments and essential oils
Historical development and SPF
History and structure
HIV infection
How does dermatology benefit from systematic reviews
How to assess the evidence for the safety of medical interventions
How to critically appraise systematic reviews and metaanalyses
Hydroxyurea
Imiquimod
Immunoglobulin
Implication for clinical practice - 2
Implications for clinical practice - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Implications for future studies
Implications for practice - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Implications for topical antibiotics in clinical practice
Implications for use of systemic antibiotics in clinical practice
Incidence
Incidence and prevalence
Incidenceprevalence - 2 3 4 5 6 7 8 9 10
Influencing the agenda of future dermatology trials
Instructions for use
Intended and actual sun protection from sunscreens
Interferon alfa plus zidovudine Efficacy
Interferon beta
Interferon versus bleomycin
Intravenous immunoglobulin
Introduction
Keeping up to date and increasing precision
Keratolytics
Key points - 2 3 4 5 6 7 8 9 10 11 12
Key points for chromoblastomycosis
Key points for mycetoma
Key points for systemic mycoses
Key points for treatment of sporotrichosis 13 14 15 16
Key points Local therapy
Key points localised disease 17
Key points Men with AGA 18 19 20 21 22
Key points Prevention 23 24 25 26 27 28 29 30 31 32 33
Large variations in terms of health care organisation
Laser therapies Efficacy
Laser therapy Benefits
Levamisole
Limitations of aggregate data
Limitations of clinical research
Liposomal anthracyclines
Longterm outcome of chronic disorders
M
Magnitude of treatment effects How big
Masoprocol
Methods
Methods of literature search
Methods of search - 2 3 4 5 6 7 8 9 10 11 12 13
Methotrexate - 2
Minimising bias and identifying research gaps
Miscellaneous
Miscellaneous topical therapies
Mohs micrographic surgery
Mortality and morbidity
Newer cytotoxic drugs
Noninsecticidebased acaricides Benefits
Olivier Chosidow
Oral antibiotics
Oral steroids Benefits
Orally administered treatments Benefits
Other factors worth looking for
Other interventions salvia
Other oral agents Benefits
Outcome measures
Outcomes - 2
Palmoplantar pustular psoriasis
Paradoxical findings problems with use of sunscreen as a primary prevention aim
The critical appraisal toolbox33
Patchy alopecia areata
Pathogenesis
Pathophysiology
Patients preferences
PDT versus cryotherapy
Personal experience
Phototherapy and photochemotherapy
Plasmapheresis
Possible drawbacks of sunscreens
Potential drawbacks - 2 3 4
Preface
Prevention
Primary journals
Prognosis - 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
Publication bias
Purine analogues Efficacy
Quality criteria derived from research
Questions Primary prevention
Rare but serious sideeffects
Recommendations for future research
Recommendations for the future
References - 2 3 4 5 6 7 8 9 10 11 12
References for localised disease 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39
Relevant outcomes - 2 3 4 5 6 7 8 9 10
Results and discussion
Retinoids Benefits
Reviews always end with the phrase insufficient evidence
Risk factors
Salicylic acid
Scenario
Scope
Search methods - 2
Search strategy
Searches
Secondary journals
Secondary prevention
Section B Skin cancer271
Section C Infective skin diseases421
Section H Less common skin disorders603
Selfcontrol design
Sensitive scales to amplify effects
Skin grafting Benefits
So is it all just another fashion that will come and go
So what would I go for
Sources of evidence within a systematic review
Step 2 Searching for the best external information
Step 3 Sifting information for relevance and quality
Step 4 Applying the evidence back to the patient
Step 5 Recording the information for the future
Summary - 2 3
Summary of the evidence base for atopic eczema
Sunscreens Efficacy
Surgical excision
Surgical interventions sympathectomy
Susan Jessop
Systemic antibiotics Efficacy
Systemic antifungal therapy for tinea capitis in children
Systemic corticosteroids Benefits
Systemic finasteride for men with AGA Efficacy
Systemic retinoid monotherapy
Systemic retinoids
Systemic therapy
Tasks undertaken by the Cochrane Skin Group
Testing and regulation of sunscreens
Tetracycline - 2
Tetracyclines Efficacy
The Cochrane Library - 2
The endemic mycoses
The field and its boundaries
The future
The hazards of quick searches
The hierarchy of evidence
The idiopathic photodermatoses
The limitations of systematic reviews
The many roles of a consumer
The principles of the Cochrane Collaboration
The use of placebo in RCTs
The value of suspicion case reports and case series
The visible nature of skin disease
Thomas Diepgen
Too many scales and too many shortterm studies
Topical agents Benefits
Topical antibiotics
Topical antibiotics Efficacy
Topical corticosteroids and intralesional injections
Topical corticosteroids Benefits
Topical mechlorethamine nitrogen mustard Efficacy
Topical nystatin
Topical retinoids Efficacy
Topical steroids Benefits
Topical treatment is often possible
Total skin electron beam therapy TSEB Efficacy
Treatment
Treatment aims
Tretinoinisotretinoin
Trials Register
Triumph of the aggregate
Troubleshooting
Uncontrolled data
Vanessa Venning
Vinca alkaloids
Vitamin D analogues
Vitamins and minerals Benefits
Weighing up risks and benefits
What are consumers
What are the patients values Values and belief models
What are the potential limitations of evidencebased dermatology Poor coverage
What evidencebased dermatology is not
What is special about dermatology
What is the point of discussing evidencebased dermatology

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