ABV chemotherapy versus doxorubicin

We found one small randomised study of 61 patients with extensive mucocutaneous or visceral AIDS-related KS, comparing ABV combination chemotherapy with doxorubicin alone.74 The overall response rate was 88% for 30 patients who received ABV combination chemotherapy and 48% for the 31 patients who received doxorubicin, 20 mg/m2, alone. The response rates differed significantly. Toxicity was similar in both arms, but neutropenia (<1000 x 106 cells/litre) was more frequent with ABV (52%) than with doxorubicin alone (34%). Median survival was 9 months for both groups.74

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