ABV or BV chemotherapy versus liposomal anthracyclines

Three large randomised controlled trials have compared liposomal anthracyclines (either doxorubicin or daunorubicin) with standard ABV or BV combination chemotherapy. We found one randomised study comparing liposomal daunorubicin (DaunoXome) with ABV and two randomised trials comparing liposomal doxorubicin with standard combination chemotherapy (either ABV or BV).60-62 All three trials assessed response using modified ACTG response criteria and graded toxicity according to standard criteria. Concurrent antiretroviral therapy was allowed in all three trials. Table 29.3 summarises the results of these trials.

A further randomised controlled trial compared pegylated liposomal doxorubicin (PLD), 20 mg/m2, alone with the combination PLD + bleomycin + vincristine (PLD, 20 mg/m2, bleomycin, 10 IU/m2, vincristine, 1 mg) given every two weeks.75

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