Quality of evidence: I
One compared 0%, 10%, 20% or 30% 5-ALA with placebo in a dose-ranging study using a 630 nm light source and a 3-hour incubation time.90 Another RCT tested a recent formulation of ALA, the Levulan Kerastick topical solution, (n = 180) with placebo (n = 61) using a 14-18 hour incubation time and illumination with BLU-U blue light (417 nm).91 The third study compared treatment of hand lesions with a 4-hour incubation with 20% 5-ALA and 580-740 nm light against topical 5% 5-FU.92
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