Adverse effects

Topical retinoids induce local reactions and should be discontinued if the reaction is severe. All studies presenting data suggested that 0-1% adapalene causes less local irritation than 0-025% tretinoin45 and that the rate of local reactions of both agents increases with concentration.28,29,45,47,51 Retinoids increase the sensitivity of skin to UV light and should therefore be applied at night and washed off in the morning. Rarely eye irritation, oedema and blistering of the skin occur, and hypopigmentation may result from tretinoin use.

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