Aetiology

The aetiology of sarcoidosis remains elusive; with immune, genetic, infectious and environmental factors all postulated to contribute. The role of genetics is supported by the existence of positive family clusters of sarcoidosis, and serological studies demonstrating that patients with certain class I and II HLA types are more susceptible.8-10 Mycobacteria have been investigated as a possible aetiological agent because of the granulomatous nature of the disease, but no definitive evidence has emerged thus far.1

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